Importance of Adult Dmbx1 in Long-Lasting Orexigenic Effect of Agouti-Related Peptide
نویسندگان
چکیده
منابع مشابه
Dmbx1 is essential in agouti-related protein action.
Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1(-/-) mouse from its cohabitants induces self-starvation, sometimes leading to death, features similar to those of anorexia nervosa in humans. Interestingly, overexpression of agouti in Dmbx1(-/-) mi...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2016
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2015-1560